Valproic acid affects chemicals in the body that may be involved in causing seizures. Valproic acid is used to treat various types of seizure disorders. Valproic acid is sometimes used together with other seizure medications. Valproic acid is also used to treat manic episodes related to bipolar disorder (manic depression), and to prevent migraine headaches. Valproic acid may also be used for purposes not listed in this medication guide.

Certificate of Analysis

• Description

  A colourless or very slightly yellow, clear liquid, slightly viscous..

  Result

  A clear colourless liquid.

• Solubility

  Very slightly soluble in water, miscible with alcohol & with methylene chloride.

  Result

  Complies

• Identification

  Should comply the test A & B.

  Result

  A & B Complies.

• Water

  Not more than 1 %

  Result

  0.46 %

• Related Substance by HPLC
  Indivisual Impurity

  Not more than 0.05 %

  Result

  Not more than 0.05 %

• Related Substance by HPLC
  Sum of all secondary impurities

  Not more than 0.2 %

  Result

  Not more than 0.2 %

• Heavy Meals

  NMT 0.002 %

  Result

  Less than 0.002 %

• Residue on ignition

  NMT 0.1 %

  Result

  0.02%

• Assay

  Between 99.0 % to 101 %

  Result

  99.92 %

• Specific gravity (Density)

  0.89 to 0.91

  Result

  0.90

• Residual Solvent
  Result

  NIL

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Material Safety Data Sheet

• Section 1 – Chemical Product

  Product Identifier

  Valproic Acid

  MSDS Prepared By

  R&D Department

• Section 2 – Composition / Information Of Ingredients

  Product Name

  Valproic Acid

  Synonym

  Dipropylacetic acid; Valproic acid

  Molecular Formula

  C8H16O2

  Molecular Weight

  144.21

  CAS Number

  99-66-1

• Section 3 – HAZARDOUS IDENTIFICATION

  Emergency Overview

  Harmful if swallowed.

  Health Effects

  Eye

  Causes eye burns.

  Skin

  Causes skin burns.

  Ingestion

  Harmful if swallowed. Causes gastrointestinal tract burns.

  Inhalation

  Causes chemical burns to the respiratory tract. Chronic: Possible risk of harm to the unborn child.

• Section 4 – FIRST AID

  Skin Contact

  Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.

  Eye Contact

  Immediately flush eyes with plenty of water for at least 15 Minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

  Inhalation

  Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

  Ingestion

  Do not induce vomiting. Get medical aid immediately.

  Notes to Physician

  Treat symptomatically.

• Section 5 – FIRE FIGHTING MEASURES

  General Information

  As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.

  Extinguishing Media

  Use foam, dry chemical, or carbon dioxide.

• Section 6 – ACCIDENT RELEASE MEASURES

  General Information

  Use proper personal protective equipment as Indicated in Section 8.

  Spills/Leaks

  Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.

• Section 7 – HANDLING AND STORAGE

  Handling

  Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.

  Storage

  Store in a cool, dry place. Store in a tightly closed container away from Corrosive area.

• Section 8 – EXPOSURE CONTROLS / PERSONAL PROTECTION

  Engineering Controls

  Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.

  Personal Protective Equipment 

  Eye Protection

  Wear chemical goggles.

  Skin

  Wear appropriate protective gloves to prevent Skin exposure.

  Clothing

  Wear appropriate protective clothing to prevent skin exposure.

  Respirators

  Follow the OSHA respirator regulations found in 29 CFR 1910. 134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

• Section 9 – PHYSICAL AND CHEMICAL PROPERITIES

  Physical State

  Clear liquid

  Colour

  Colourless

  Odor

  N/A

  pH

  N/A

  Vapor Pressure

  N/A

  Viscosity

  N/A

  Boiling Point

  220 ° C

  Melting Range

  N/A

  Auto-ignition Temperature

  N/A

  Flash Point

  111 ° C

  Explosion Limits, lower

  N/A

  Explosion Limits, upper

  N/A

  Decomposition Temperature

  N/A

  Solubility in Water

  Slightly soluble.

  Specific Gravity/ Density

  0.920

• Section 10 – STABILITY AND REACTIVITY

  Chemical stability

  N/A

  Conditions to avoid

  N/A

  Incompatibilities with Other Materials

  Oxidizing agents, reducing agents, bases.

  Hazardous Decomposition Products

  Carbon monoxide, carbon dioxide.

  Hazardous Polymerization

  Will not occur.

• Section 11 – TOXICOLOGICAL INFORMATION

  RTECS#:

  CAS# 99-66-1

  LD50/LC50:

  CAS# 99-66-1

  Oral, mouse: LD50 = 1098 mg/kg;

  Oral, rat

  LD50 = 670 mg/kg.

  Carcinogenicity

  2-Propylpentanoic acid -Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. See actual entry in RTECS for complete information.

• Section 12 – ECOLOGICAL INFORMATION

  No data Available.

• Section 13 – DISPOSAL CONSIDERATION

  General Information

  Dispose of in a manner consistent with federal, state, and local regulations.

• Section 14 – TRANSPORT INFORMATION

  DOT

  Not regulated as hazardous material by DOT.

  IATA

  Not regulated as dangerous goods.

• Section 15 – REGULATORY INFORMATION

  European/International Regulations

  Directives Hazard Symbols

  T

  Risk Phrases

  R61

  May cause harm to the unborn child.

  R22

  Harmful if swallowed

  R34

  Causes burns.

  Safety Phrases

  S53

  Avoid exposure – obtain special instructions before use.

  S26

  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

  S36/37/39

  Wear suitable protective clothing, Gloves and eye/face protection.

  S45

  In case of accident or if you feel unwell, seek medical advice immediately (show the label Where possible).

  WGK (Water Danger/Protection)

  CAS# 99-66-1

  No information available. United Kingdom Occupational Exposure Limits United Kingdom Maximum Exposure Limits Canada. None of the chemicals in this product are listed on the DSL/NDSL list.CAS# 99-66-1 is not listed on Canada’s Ingredient Disclosure List.

  Exposure Limits US FEDERAL TSCA

  CAS# 99-66-1

  Is not listed on the TSCA inventory. It is for research and development use only.

• Section 16 – OTHER INFORMATION

  Global Pharma provides information contained herein in good faith but makes no representation as to its comprehensives or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product.

  Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.

  GLOBAL PHARMA MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESSED OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OR MERCHANTABILITY, FITNESS FOR A PARTICULER PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT WHICH THE INFORMATION REEFERS. GLOBAL PHARMA WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF RELIANCE UPON THIS INFORMATION.