Minoxidil

Minoxidil is a vasodilator that relaxes (widens) blood vessels and improves blood flow.

Minoxidil is used to treat severely high blood pressure (hypertension) that is causing symptoms or damaging your vital organs. Minoxidil is usually given together with two other medicines to help prevent serious side effects.

Minoxidil tablets should not be used to promote scalp hair growth. Only the topical form of minoxidil (Rogaine) is recommended for that use.

Minoxidil may also be used for purposes not listed in this medication guide.

 

Certificate of Analysis

  • Description

    White or Off-white crystalline powder.

    Result

    White crystalline powder.

  • Identification (by IR)

    Should match with Standard.

    Result

    Complies.

  • pH (in a mixture with water (1.5: 100)

    3.0 – 4.0

    Result

    3.5

  • Moisture content

    NMT 2.0 %

    Result

    0.5 %

  • Residue on Ignition

    NMT 0.5 %

    Result

    0.2 %

  • Minoxidil content (by HPLC)

    50.0 – 60.0 % w/w.

    Result

    54.1 % w/w.

  • Oxothiazolidine Carboxylic AcidContent (By titration)

    40.0 % – 50.0 % w/w.

    Result

    40.9 % w/w.

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Material Safety Data Sheet

  • Section 1 – Chemical Product

    Product Identifier

    Minoxidil

    MSDS Prepared By

    R&D Department

  • Section 2 – Composition / Information Of Ingredients

    Product Name

    Minoxidil

    Synonym

    6-(Piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide

    CAS Number

    38304-91-5

  • Section 3 – HAZARDOUS IDENTIFICATION

    Hazard Class and Category Code(s)

    Acute Toxic Oral

    4

    Skin Irritant

    2

    Eye Irritant

    2

    Stot Se

    3

    Hazard Statement Code(s)

    H302

    Harmful if swallowed.

    H315

    Causes skin irritation.

    H319

    Causes serious eye irritation.

    H335

    May cause respiratory irritation.

    Precautionary Statement

    P261

    Avoid breathing dust / fume / gas / mist / vapours / spray.

    P264

    Wash hands & other exposed areas thoroughly after handling.

    P301+P312

    IF SWALLOWED: Call a POSION CENTER or doctor / physician if you feel unwell.

    P330

    Rinse mouth.

    P280

    Wear protective gloves / protective clothing / eye protection / face protection.

    P305+P351+P338

    IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present & easy to do. Continue rising.

    P501

    Dispose of contents / containers in accordance with local regulation.

    Single Word

    Warning

  • Section 4 – FIRST AID

    General Information

    If exposed or concerned. Get medical advice / attention.

    Eye Contact

    Remove contact lenses, if work & rinse open eye with at least 15 minutes under running water & apply sterile protective bandage. Obtain medical attention immediately.

    Skin Contact

    Remove contaminated clothing & wash affected area with soap & water immediately. If irritation or redness occurs obtain immediate medical attention.

    Inhalation

    Move to fresh air. Assure fresh air breathing. If breathing has ceased give artificial respiration. Obtain immediate medical attention.

    Ingestion

    Never give anything by mouth if patient is unconscious. Do not induce vomiting. Rinse mouth with water & obtain immediate medical attention.

    Other Information

    Treat symptomatically.

  • Section 5 – FIRE FIGHTING MEASURES

    Suitable Extinguishing Media

    Use extinguishing media appropriate for surrounding fire. Water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

    Exposure Hazards

    Carbon oxides, nitrogen oxides.

    Fire Fighting Procedures

    A self-contained breathing apparatus & suitable protective clothing should be worn by fire fighters.

  • Section 6 – ACCIDENT RELEASE MEASURES

    Personal Precautions

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas, avoid breathing dust.

    Environmental Precautions

    Do not let enter drains.

    Disposal

    Disposal of waste in accordance with all applicable federal, state and local laws.

    Methods for Cleaning-up

    Take up mechanically or sweep up carefully & transfer to a suitable container for recovery or waste disposal. Avoid generation of dust. Ventilate the area & wash spill site after material pick-up is complete.

  • Section 7 – HANDLING AND STORAGE

    Handling

    Avoid contact with skin & eyes. Avoid formation of dust & aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection.

    Storage

    Store in cool place. Keep container tightly closed in a dry & well-ventilated place.

  • Section 8 – EXPOSURE CONTROLS / PERSONAL PROTECTION

    Exposure Controls

    Handle in accordance with good industrial hygiene & safety practice. Wash hands before breaks & at the end of workday.

    Occupational Exposure Controls

    Wear recommended personal protective equipment as details below.

    Personal Protection

    Chemical resistant gloves & safety glasses is must.

    Respiratory Protection

    Seek professional advice prior to respirator selection. Atmospheric level should be maintained below exposure limit. If airborne concentrations is high use mask or respirator.

    Hand Protection

    Wear chemical protective gloves.

    Eye Protection

    Wear Safety glasses.

    Skin Protection

    Wear chemical protective clothing.

    Work Practices

    Eye wash facilities & a safety shower should be easily accessible. Before breaks & at the end of work thoroughly wash hands with soap & water. Wash contaminated clothing before use. Clean footwear before use.

    Environmental exposure Controls

    All necessary precautions must be taken to avoid release into the environment. Refer to Local, State or Nationals Legislations for environment & pollution control.

  • Section 9 – PHYSICAL AND CHEMICAL PROPERITIES

    Appearance

    Crystalline, White powder

    Odour

    N/A

    Odour Threshold

    N/A

    pH

    N/A

    Melting Point / Freezing Point

    Melts with approx. 248° – 268° C with decomposition

    Initial Boiling Point

    N/A

    Flash Point

    N/A

    Evaporation Rate

    N/A

    Flammability

    N/A

    Upper Explosive Limit

    N/A

    Lower Explosive Limit

    N/A

    Vapor Pressure

    N/A

    Vapor Density

    N/A

    Relative Density

    N/A

    Solubility(ies)

    Soluble in alcohol & in propylene glycol, sparingly soluble in methanol, slightly soluble in water, practically insoluble in chloroform, in acetone, in ethyl acetate & in hexane.

    Partition Coefficient

    N/A

    Auto-Ignition Temperature

    N/A

    Decomposition Temperature

    N/A

    Viscosity

    N/A

    Explosive Properties

    N/A

    Oxidising Properties

    N/A

  • Section 10 – STABILITY AND REACTIVITY

    Stable

    Stable & no hazardous polymerization.

    Condition to avoid

    Usual precautions for handling of chemicals should be observed.

    Material to Avoid

    Avoid contact with oxidizing substances.

    Reactivity

    N/A

  • Section 11 – TOXICOLOGICAL INFORMATION

    Acute Toxicity

    LD50 Oral (Rat) 1321 mg/kg

    Ingestion

    Harmful if swallowed.

    Inhalation

    May cause respiratory irritation.

    Skin Contact

    May be harmful if absorbed through skin. Causes skin irritation.

    Eye Contact

    Causes serious eye irritation.

  • Section 12 – ECOLOGICAL INFORMATION

    Aquatic Toxicity

    N/A

    Persistence & Degradability

    N/A

    Bioaccumulate Potential

    N/A

    Mobility in Soil

    N/A

    Other adverse Effects

    N/A

  • Section 13 – DISPOSAL CONSIDERATION

    Waste Treatment

    Contact a licensed professional waste disposal service to dispose of this material. Dispose in a safe manner in accordance with local / national regulations.

  • Section 14 – TRANSPORT INFORMATION

    D.O.T. Label

    None

    Land Transport

    ADR / RID / GGVS / GGVE UN NO

    None / Not Regulated

    Sea Transport

    IMDG

    None / Not Regulated

    Air Transport

    IATA

    None / Not Regulated

  • Section 15 – REGULATORY INFORMATION

    Hazard Class and Category Code(s)

    Acute Toxic Oral

    4

    Skin Irritant

    2

    Eye Irritant

    2

    Stot Se

    3

    Hazard Statement Code(s)

    H302

    Harmful if swallowed.

    H315

    Causes skin irritation.

    H319

    Causes serious eye irritation.

    H335

    May cause respiratory irritation.

    Single Word

    Warning

  • Section 16 – OTHER INFORMATION

    Global Pharma provides information contained herein in good faith but makes no representation as to its comprehensives or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product.

    Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.

    GLOBAL PHARMA MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESSED OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OR MERCHANTABILITY, FITNESS FOR A PARTICULER PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT WHICH THE INFORMATION REEFERS. GLOBAL PHARMA WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF RELIANCE UPON THIS INFORMATION.

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