L-arginine is an amino acid naturally found in red meat, poultry, fish, and dairy. It is necessary for making proteins and is commonly used for circulation.

L-arginine is converted in the body into a chemical called nitric oxide. Nitric oxide causes blood vessels to open wider for improved blood flow. L-arginine also stimulates the release of growth hormone, insulin, and other substances in the body. It can be made in a lab and used in supplements.

Certificate of Analysis

• Appearance

  White or almost white, crystalline powder or colorless crystals, hygroscopic.

• Solubility

  Freely soluble in water, very slightly soluble in ethanol. (96 per cent).

• Identification By IR

  To match with the reference IR spectrum

• Identification By TLC

  The principal spot in the chromatogram obtained with the test solution is similar in position, color and size to the principal spot in the chromatogram obtained with the reference solution.

• Chloride

  NMT 0.05 %

• Sulphate

  NMT 0.03 %

• Iron

  NMT 30 ppm

• Residue on Ignition

  NMT 0.3 %

• Specific Rotation

  +26.3° ~ +27.7°

• Heavy Metal

  NMT 10 ppm

• Loss on drying

  NMT 0.5 %

• Organics Impurities by TLC

• Individual Impurities

  NMT 0.5 %

• Total Impurities

  NMT 2.0 %

• Assay by Titration

  NLT 98.5 & NMT 101.5 %

Note: Note: – We are leading channel partner of much API manufacturer, supplier & exporters and Pharmaceutical raw material in Colombo, Chili, Ecuador and Globally.

Material Safety Data Sheet

• • Section 1 – Chemical Product

    Product Identifier

    L-Arginine Base

    MSDS Prepared By

    R&D Department

  • Section 2 – Composition / Information Of Ingredients

    Product Name

    L-Arginine Base

    Chemical Name

    (S)-2-Amino-5-guanidinopentanoic acid

    EINECS #

    200-811-1

    Synonym

    (S)-2-Amino-5-guanidinopentanoic acid

    Molecular Formula

    C6H14N4O2

    Molecular Weight

    174.2 g/mol

    CAS Number

    74-79-3

  • Section 3 – HAZARDOUS IDENTIFICATION

    Classification of the substance or mixture

     .

    Classification according to Regulation (EC) No 1272/2008

    Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

    Label elements

    Labelling according Regulation (EC) No 1272/2008

    Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

    Other Hazards

    This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

  • Section 4 – FIRST AID

    After inhalation

    Fresh air

    Skin Contact

    In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.

    Eye Contact

    RRinse out with plenty of water. Remove contact lenses.

    Swallowed

    Make victim drink water (two glasses at most). Consult doctor if feeling unwell.

    Most important symptoms and effects, both acute and delayed

    The most important known symptoms and effects are described in the labelling (see secti2.2) and/or in section 11

    Indication of any immediate medical attention and special treatment needed

    N/A

  • Section 5 – FIRE FIGHTING MEASURES

    Extinguishing media

    Suitable extinguishing media

    Water Foam Carbon dioxide (CO2) Dry powder

    Unsuitable extinguishing media

    For this substance/mixture no limitations of extinguishing agents are given.

    Special hazards arising from the substance or mixture

    Carbon oxides Nitrogen oxides (NOx) Combustible. Fire may cause evolution of: nitrogen oxides Development of hazardous combustion gases or vapours possible in the event of fire.

    Advice for firefighters

    In the event of fire, wear self-contained breathing apparatus.

    Further information

    Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

  • Section 6 – ACCIDENT RELEASE MEASURES

    Personal precautions, protective equipment and emergency procedures

    Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area, observe emergency procedures, consult an expert.

    Environmental precautions

    Do not let product enter drains.

    Methods and materials for containment and cleaning up

    Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.

    Reference to other sections

    For disposal see section 13.

  • Section 7 – HANDLING AND STORAGE

    Precautions for safe handling

    For precautions see section 2.2.

    Storage

    Tightly closed. Dry. Store at +5°C to +30°C.

    Specific end use(s)

    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.

  • Section 8 – EXPOSURE CONTROLS / PERSONAL PROTECTION

    Control parameters

    Ingredients with workplace control parameters.

    Personal protective equipment

    Eye/face protection

    SUse equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses.

    Skin protection

    This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

 

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Respiratory protection

required when dusts are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Control of environmental exposure

Do not let product enter drains.

• Section 9 – PHYSICAL AND CHEMICAL PROPERITIES

  Physical state and appearance

  Solid.

  Color

  White.

  Odor

  Weak

  Odor Threshold

  N/A

  pH

  ca.11,4 at 100 g/l at 20 °C

  Melting Point/freezing Point

  Melting point/range: 223 – 224 °C at ca.1.013 hPa

  Initial boiling point and boiling range

  N/A

  Flash Point

  N/A

  Evaporation rate

  Flammability (solid, gas) The product is not flammable

  Flammability (solids)

  Upper/lower flammability or explosive limits

  N/A

  Vapor Pressure

  < 0,1 hPa at 25 °C

  Vapor Density

  N/A

  Relative density

  1,1 g/cm

  Water solubility

  182 g/l at 25 °C – completely soluble

  Viscosity kinematic

  N/A

  Viscosity dynamic

  N/A

  Explosive Properties

  N/A

  Oxidizing Properties

  N/A

  Bulk density

  ca.640 kg/m³

  Dissociation constant

  2,17 at 20 °C

• Section 10 – STABILITY AND REACTIVITY

  Reactivity

  The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

  Chemical stability

  The product is chemically stable under standard ambient conditions (room temperature).

  Possibility of hazardous reactions

  Violent reactions possible with

  Strong oxidizing agents

  Conditions to avoid

  N/A

  Incompatible materials

  N/A

  Hazardous decomposition products

  In the event of fire: see section 5

• Section 11 – TOXICOLOGICAL INFORMATION

  Information on toxicological effects

  Acute toxicity

  LD50 Oral – Rat – male and female

  > 5.110 mg/kg Remarks: (ECHA)

  Skin corrosion/irritation

  Skin

  Rabbit

  Result

  No skin irritation – 4 h

  Serious eye damage/eye irritation

  Eyes

  Rabbit

  Result

  No eye irritation – 1 h

  Respiratory or skin sensitization

  N/A

  Germ cell mutagenicity

  Mutagenicity (mammal cell test)

  chromosome aberration. Human lymphocytes

  Result

  Negative

  Carcinogenicity

  IARC

  No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

  Reproductive toxicity

  N/A

  Specific target organ toxicity – single exposure

  N/A

  Specific target organ toxicity – repeated exposure

  N/A

  Aspiration hazard

  N/A

• Section 12 – ECOLOGICAL INFORMATION

  Toxicity

  Toxicity to fish semi-static test LC50 – Danio rerio (zebra fish) – 2.800 mg/l – 96 h (OECD Test Guideline 203)

  Persistence and degradability

  Biodegradability aerobic

  Exposure time 28 d

  Bioaccumulative potential

  N/A

  Mobility in soil

  N/A

  Results of PBT and vPvB assessment

  This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

  Other adverse effects

  N/A

• Section 13 – DISPOSAL CONSIDERATION

  Waste treatment methods

  Product

  Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and nonrecyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.;

  Contaminated packaging

  Dispose of as unused product.

• Section 14 – TRANSPORT INFORMATION

  UN number

  ADR/RID

  IMDG – IATA

  UN proper shipping name

  ADR/RID

  Not dangerous goods

  IMDG

  Not dangerous goods

  IATA

  Not dangerous goods

  Transport hazard class(es)

  ADR/RID

  IMDG – IATA

  Packaging group

  ADR/RID

  IMDG – IATA

  Environmental hazards

  ADR/RID

  No IMDG Marine pollutant: no IATA: no

  Further information

  Not classified as dangerous in the meaning of transport regulations.

• Section 15 – REGULATORY INFORMATION

  Safety, health and environmental regulations/legislation specific for the substance or mixture

  Millipore

  1.01542 Page 8 of 8. The life science business of Merck operates as MilliporeSigma in the US and Canada. This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006.

  National legislation

  Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances. Not applicable

  Chemical Safety Assessment

  For this product a chemical safety assessment was not carried out.

• Section 16 – OTHER INFORMATION

  Global Pharma provides information contained herein in good faith but makes no representation as to its comprehensives or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product.

  Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.

  GLOBAL PHARMA MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESSED OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OR MERCHANTABILITY, FITNESS FOR A PARTICULER PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT WHICH THE INFORMATION REEFERS. GLOBAL PHARMA WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF RELIANCE UPON THIS INFORMATION.