Hydroquinone decreases the formation of melanin in the skin. Melanin is the pigment in skin that gives it a brown color.

Hydroquinone topical (for the skin) is used to lighten areas of darkened skin such as freckles, age spots, melasma(sun damage), or chloasma (darkened skin caused by hormonal changes).

Hydroquinone topical may also be used for purposes not listed in this medication guide.

Certificate of Analysis

• Description

  White to almost white, crystalline powder.

  Result

  Complies

• Identification by IR

  Positive

  Result

  Positive

• Identification by Na

  Negative

  Result

  Negative

• Solubility

  Practically insoluble in Water, Freely soluble in Ethanol

  Result

  Complies

• Optical Rotation

  -7° to -12° c

  Result

  -9.4° C

• Water

  1.4 to 2.0 %

  Result

  1.8%

• Sulphated Ash

  NMT 0.2%

  Result

  0.01%

• Residue Solvents

  99.0% to 100.5%

  Result

  99.63%

Note: Note: – We are leading channel partner of much API manufacturer, supplier & exporters and Pharmaceutical raw material in Colombo, Chili, Ecuador and Globally.

Material Safety Data Sheet

• Section 1 – Chemical Product

  Product Identifier

  Hydroquinone

  MSDS Prepared By

  R&D Department

• Section 2 – Composition / Information Of Ingredients

  Product Name

  Hydroquinone

  Synonymous Name

  1,4-benzenedio

  CAS Number

  123-31-9

• Section 3 – HAZARDOUS IDENTIFICATION

  Health Hazard

  Acute toxicity (Oral)

  Category 4

  Serious eye damage

  Category 1

  Skin Sensitizer

  Category 1

  Germ Cell Mutagenicity

  Category 2

  Specific Target Organ Toxicity – Single Exposure (Dermal)

  Category 2

  OSHO Specified Hazards

  Combustible Dust

  If converted to small particles during further processing, handling or by other means may form combustible dust concentrations in air.

  Signal Words

  Danger!

  Hazards Statements

  H302

  Harmful if swallowed.

  H318

  Causes serious eye damage.

  H317

  May cause an allergic skin reaction.

  H341

  Suspected of causing genetic defects.

  H371

  May cause damage to organs. If converted to small particles during further processing, handling or by other means may form combustible dust concentrations in air.

  Precautionary Statements

  Preventions

  P201

  Obtain special instructions before use.

  P202

  Do not handle until all safety precautions have been read and understood.

  P281

  Use personal protective equipment as required

  P264

  Wash hands thoroughly after handling.

  P270

  Do not eat, drink or smoke when using this product.

  P260

  Do not breathe dust / fume / gas / mist / vapors / spray.

  P280

  Wear protective gloves / Protective clothing / Eye protection / Face protection

  P272

  Contaminated work clothing should not be allowed out of the workplace.

  Response

  P309+P311

  IF exposed or if you feel unwell: Call a POISON CENTER or doctor / physician.

  P301+P312

  IF SWALLOWED: Call a POISON CENTER or doctor / physician if you feel unwell.

  P330

  Rinse mouth

  P302+P352

  IF ON SKIN: Wash with plenty of soap and water.

  P333+P313

  If skin irritation or rash occurs: Get medical advice / attention.

  P363

  Wash contaminated clothing before reuse.

  P305+P351+P338

  IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

  P310

  Immediately

  Storage

  P405

  Store locked up.

  Disposal

  P501

  Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

• Section 4 – FIRST AID

  Skin Contact

  Immediately remove contaminated clothing and shoes and wash skin with soap and plenty of water. If skin irritation or an allergic skin reaction develops, get medical attention. Wash contaminated clothing before reuse. Destroy or thoroughly clean contaminated shoes.

  Eye Contact

  Immediately flush with plenty of water for at least 15 minutes. If easy to do, remove contact lenses. Get medical attention. In case of irritation from airborne exposure, move to fresh air. Get medical attention if symptoms persist.

  Inhalation

  Move to fresh air. Treat symptomatically. Get medical attention if symptoms persist.

  Ingestion

  Call a physician or poison control centre immediately. Only induce vomiting at the instruction of medical personnel. Never give anything by mouth to an unconscious person.

  Important Information

  Call a physician or poison control centre immediately. Only induce vomiting at the instruction of medical personnel. Never give anything by mouth to an unconscious person.

  Hazards

  N/A

  Treatment

  Treat symptomatically

• Section 5 – FIRE FIGHTING MEASURES

  General Fire Hazards

  Material can accumulate static charges which may cause an electrical spark (ignition source). Use proper bonding and/or grounding procedures.

  Extinguishing Media

  Suitable Extinguishing Media

  N/A

  Unsuitable Extinguishing Media

  Water spray. Dry chemical. Carbon Dioxide. Water spray. Carbon Dioxide. Dry chemical.

  Special hazards arising from the substance or mixture

  Powdered material may form explosive dust-air mixtures

  Advice for Fire-Fighters

  Special Fire-Fighting Procedures

  Minimize dust generation and accumulation.

  Special protective equipment for fire-fighters

  Self-contained breathing apparatus and full protective clothing must be worn in case of fire.

• Section 6 – ACCIDENT RELEASE MEASURES

  Personal Precautions

  Wear appropriate personal protective equipment.

  Environmental Precautions

  Do not release into the environment.

  Methods and material for containment and cleaning up

  Sweep up and place in a clearly labeled container for chemical waste. Large Spillages: Flush spill area with water spray. Prevent runoff from entering drains, sewers, or streams. Dike for later disposal.

  Notification Procedures

  In the event of a spill or accidental release, notify relevant authorities in accordance with all applicable regulations.

• Section 7 – HANDLING AND STORAGE

  Handling

  Avoid breathing dust. Avoid contact with eyes, skin, and clothing. Do not taste or swallow. Use only with adequate ventilation. Wash thoroughly after handling.

  Storage

  Keep container closed. Keep away from food, drink and animal feeding stuffs.

  Specific end user(s)

  Inhibitor Chemical Intermediate Photographic processing chemical.

• Section 8 – EXPOSURE CONTROLS / PERSONAL PROTECTION

  Appropriate Engineering Controls

  Good general ventilation (typically 10 air changes per hour) should be used. Ventilation rates should be matched to conditions. If applicable, use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits. If exposure limits have not been established, maintain airborne levels to an acceptable level.

  Personal Protective Equipment

  General information

  Eye bath. Washing facilities. Safety shower.

  Eye / Face Protection

  Chemical goggles and face shield are recommended. Wear a full-face respirator, if needed.

  Skin / Hand Protection

  Wear chemical-resistant gloves, footwear, and protective clothing appropriate for the risk of exposure. Contact health and safety professional or manufacturer for specific information. Wash hands after contact.

  Respiratory Protection

  If engineering controls do not maintain airborne concentrations below recommended exposure limits (where applicable) or to an acceptable level (in countries where exposure limits have not been established), an approved respirator must be worn. In the United States of America, if respirators are used, a program should be instituted to assure compliance with OSHA Standard 63 FR 1152, January 8, 1998. Respirator type: Air- purifying respirator with an appropriate, government approved (where applicable), air-purifying filter, cartridge or canister. Contact health and safety professional or manufacturer for specific information.

  Hygiene Measures

  Observe good industrial hygiene practices.

  Environmental Controls

  N/A

• Section 9 – PHYSICAL AND CHEMICAL PROPERITIES

  Physical State

  Solid

  Form

  Solid (Crystal)

  Odor

  Odorless

  Odor Threshold

  N/A

  Melting Point

  172.3 °C

  Boiling Point

  287 °C

  Flash Point

  165 °C (closed cup)

  Evaporation Rate

  N/A

  Flammability (Solid, Gas)

  N/A

  Flammability Limit – Upper (%)

  N/A

  Flammability Limit – Lower (%)

  N/A

  Vapor Pressure

  0.000032 hPa (25 °C)

  Vapor density (air=1)

  3.8

  Specific Gravity

  1.33 (15 °C)

  Solubility in Water

  72 g/l (25 °C)

  Solubility (other)

  N/A

  Partition coefficient (n-octanol/water)

  log Pow: 0.59

  Autoignition Temperature

  515 °C

  Decomposition Temperature

  Thermal stability not tested. Low stability hazard expected at normal operating temperatures.

  Dynamic Viscosity

  N/A

  Kinematic Viscosity

  N/A

  Explosive Properties

  N/A

  Oxidizing Properties

  N/A

• Section 10 – STABILITY AND REACTIVITY

  Reactivity

  No

  Chemical Stability

  Stable

  Possibility of Hazardous Reactions

  N/A

  Conditions to Avoid

  Heat, sparks, flames, Light.

  Incompatible Materials

  Strong oxidizing agents. Strong alkalis.

  Hazardous Decomposition Products

  Carbon Dioxide. Carbon Monoxide.

• Section 11 – TOXICOLOGICAL INFORMATION

  Information on likely routes of exposure

  Inhalation

  No

  Ingestion

  Harmful if swallowed.

  Skin Contact

  May cause an allergic skin reaction. May cause skin depigmentation.

  Eye Contact

  Causes serious eye damage.

  Incompatible Materials

  Strong oxidizing agents. Strong alkalis.

  Specified Substance(s)

  Hydroquinone

  Oral LD-50: (Rat): > 375 mg/kg

  Dermal

  Product

  N/A

  Specified Substance(s)

  Hydroquinone

  Dermal LD-50: (Rabbit): > 2,000 mg/kg

  Inhalation

  Product

  N/A

  Repeated Dose Toxicity

  Product

  N/A

  Specified Substance(s)

  Hydroquinone

  NOAEL (Rat, Oral Study. 90 d) : 20 ng/kg – NOAEL (Rat, Dermal Study. 90 d) : 73.9 ng/kg (highest dose tested)

  Skin Corrosion/Irritation

  Product

  N/A

  Specified Substance(s)

  Hydroquinone

  N/A

  Serious Eye Damage / Eye Irritation

  Product

  N/A

  Specified Substance(s)

  Hydroquinone

  (Human): corneal opacity

  Respiratory or Skin Sensitization

  Product

  N/A

  Specified Substance(s)

  Hydroquinone

  Skin Sensitization: (Mouse) : Sensitizing / Skin Sensitization: (Guinea Pig) : Not a skin Sensitizer.

  Carcinogenicity

  Product

  N/A

  Toxicity to Reproduction

  Product

  N/A

  Developmental Toxicity

  Product

  N/A

  Germ Cell Mutagenicity

  Product

  N/A

  Specified Substance(s)

  Hydroquinone

  Mutagenicity – Bacterial: negative / Chromosomal aberration: negative / Chromosomal aberration: positive / Chromosomal aberration: negative / Mutagenicity – Mammalian: positive

  In Vivo

  Product

  N/A

  Specified Substance(s)

  Hydroquinone

  Chromosomal aberration intraperitoneal injection (Mouse): Positive / Chromosomal aberration oral Gavage (Rat): Negative

  Specific Target Organ Toxicity

  Product

  N/A

  Single Exposure Specific Target

  Product

  N/A

  Organ Toxicity – Repeated Exposure

  Product

  N/A

  Aspiration Hazard

  Product

  N/A

• Section 12 – ECOLOGICAL INFORMATION

  Ecotoxicity

  Acute hazards to the aquatic Environment

  Fish

  Product

  N/A

  Specified Substance(s)

  Hydroquinone

  LC-50 (Fish, 96 h): 0.638 mg/l

  Aquatic Invertebrates

  Product

  N/A

  Specified Substance(s)

  Hydroquinone

  EC-50 (daphnid, 48 h): 0.134 mg/l

  Chronic hazards to the aquatic Environment

  Fish

  Aquatic Invertebrates

  Product

  N/A

  Specified Substance(s)

  Hydroquinone

  NOEC: (daphnid, 21 d): 0.0057 mg/l

  Toxicity to Aquatic Plants

  Product

  N/A

  Aquatic Invertebrates

  Product

  N/A

  Specified Substance(s)

  Hydroquinone

  EC-50 (Alga, 72 n) 0.33 mg/l – NOEC (Alga, 72 n) 0.019 mg/l

  Persistence and Degradability Biodegradation

  Product

  N/A

  Specified Substance(s)

  Hydroquinone

  70 % (14 d, Ready Biodegradability: Modified MITI Test (I)) Readily biodegradable

  BOD/COD Ratio

  Product

  N/A

  Bioaccumulative Potential Bioconcentration Factor (BCF)

  Product

  N/A

  Partition Coefficient n-octanol / Water (log Kow)

  Product

  Log Kow: 0.59 20 °C

  Mobility in Soil

  N/A

  Known or Oredicted Distribution to Environmental Compartments

  Hydroquinone

  Log Koc: 0.97 – 1.7 (QSAR model)

  Other Adverse Effect

  N/A

• Section 13 – DISPOSAL CONSIDERATION

  General Information

  N/A

  Disposal Methods

  Dispose of waste and residues in accordance with local authority requirements. Incinerate. Since emptied containers retain product residue, follow label warnings even after container is emptied.

• Section 14 – TRANSPORT INFORMATION

  Important Note

  Shipping descriptions may vary based on mode of transport, quantities, package size, and/or origin and destination. Consult your company’s Hazardous Materials/Dangerous Goods expert for information specific to your situation.

  DOT

  Class 9, Packing Group III when material is shipped in quantities in one package at or above the Reportable Quantity and when no other hazard class applies; otherwise, not regulated.

  Possible Shipping Description

  UN 3077 Environmentally hazardous substances, solid, n.o.s. (hydroquinone)

  IMDG

  Marine pollutant.: (hydroquinone)

  Possible Shipping Description

  UN 3077 ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (hydroquinone)

  IATA Possible Shipping Description

  UN 3077 Environmentally hazardous substance, solid, n.o.s. (hydroquinone)

• Section 15 – REGULATORY INFORMATION

  OSHA

  Hazardous

  TSCA (US Toxic Substances Control Act)

  This product is listed on the TSCA inventory. Any impurities present in this product are exempt from listing.

  DSL (Canadian Domestic Substances List) and CEPA (Canadian Environmental Protection Act)

  This product is listed on the DSL or otherwise complies with CEPA new substance notification requirements.

  AICS / NICNAS (Australian Inventory of Chemical Substances and National Industrial Chemicals Notification and Assessment Scheme)

  This product is listed on AICS or otherwise complies with NICNAS.

  MITI (Japanese Handbook of Existing and New Chemical Substances)

  This product is listed in the Handbook or has been approved in Japan by new substance notification.

  ECL (Korean Toxic Substances Control Act)

  This product is listed on the Korean inventory or otherwise complies with the Korean Toxic Substances Control Act.

  HMIS Hazard Ratings

  Health

  2*

  Flammability

  1

  Chemical Reactivity

  0

• Section 16 – OTHER INFORMATION

  Global Pharma provides information contained herein in good faith but makes no representation as to its comprehensives or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product.

  Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.

  GLOBAL PHARMA MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESSED OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OR MERCHANTABILITY, FITNESS FOR A PARTICULER PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT WHICH THE INFORMATION REEFERS. GLOBAL PHARMA WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF RELIANCE UPON THIS INFORMATION.