Chlorpromazine is an anti-psychotic medication in a group of drugs called phenothiazine’s (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain.

Chlorpromazine is used to treat psychotic disorders such as schizophrenia or manic-depression, and severe behavioural problems in children ages 1 through 12.

Chlorpromazine is also used to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus.

Chlorpromazine may also be used for purposes not listed in this medication guide.

Certificate of Analysis

• Description

  White or creamy-white, crystalline powder; odourless. It decomposes on exposure to air & light becoming yellow, pink & finally violet.

  Result

  Creamy-white crystalline powder

• Solubility

  Very soluble in water, freely soluble in ethanol (95 %); soluble in chloroform; practically insoluble in ether.

  Result

  Complies

• Identification by IR

  The IR spectrum of the sample should concordant with that of working standard.

  Result

  Sample spectrum was concordant with working standard spectrum.

• Identification by UV Absorption

  The absorbance at the maximum at 254 nm is 0.45 to 0.48.

  Result

  0.465 Abs

• Identification by Test for phenothiazines

  To comply the test.

  Result

  Complies

• Identification by Test for chloride

  Between 3.5 to 4.5

  Result

  3.96

• Related substance (By TLC) Any impurity

  Not more than 0.5 %

  Result

  Less than 0.5 %

• Heavy Meals

  Not more than 10 ppm

  Result

  Less than 10 ppm

• Loss on drying

  Not more than 0.5 %

  Result

  0.19 %

• Sulphated Ash

  Not more than 0.1 %

  Result

  0.06 %

• Assay

  99.0 % to 101.0 % (Calculated with reference to the dried substance)

  Result

  100.14 %

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Material Safety Data Sheet

• Section 1 – Chemical Product

  Product Identifier

  Chlorpromazine HCL

  MSDS Prepared By

  R&D Department

• Section 2 – Composition / Information Of Ingredients

  Product Name

  Chlorpromazine HCL

  Synonym

  2-Chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine hydrochloride

  Molecular Formula

  C17H19ClN2S.HCl

  Molecular Weight

  355.33 g/mole

  CAS Number

  69-09-0

• Section 3 – HAZARDOUS IDENTIFICATION

  Potential Acute Health Effects

  Extremely hazardous in case of inhalation. Very hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion. Severe over-exposure can result in death. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering.

  Potential Chronic Health Effects

  Extremely hazardous in case of inhalation. Very hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion.

  Carcinogenic Effects

  N/A

  Mutagenic Effects

  N/A

  Teratogenic Effects

  N/A

  Developmental Toxicity

  N/A. The substance is toxic to blood, the nervous system, liver. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or many human organs. Repeated or prolonged exposure is not known aggravate medical condition.

• Section 4 – FIRST AID

  Eye Contact

  Check for and remove any contact lenses. Do not use an eye ointment. Seek medical attention.

  Skin Contact

  After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cold water may be used. Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated clothing before reusing.

  Serious Skin Contact

  Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.

  Inhalation

  Allow the victim to rest in a well-ventilated area. Seek immediate medical attention.

  Serious Inhalation

  Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medical attention.

  Ingestion

  Do not induce vomiting. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.

  Serious Ingestion

  N/A

• Section 5 – FIRE FIGHTING MEASURES

  Flammability of the Product

  May be combustible at high temperature.

  Auto-Ignition Temperature

  N/A

  Flash Points

  N/A

  Flammable Limits

  N/A

  Products of Combustion

  These products are carbon oxides (CO, CO2), sulphur oxides (SO2, SO3…) halogenated compounds.

  Fire Hazards in Presence of Various Substances

  N/A

  Explosion Hazards in Presence of Various Substances

  Risks of explosion of the product in presence of mechanical impact

  N/A

  Risks of explosion of the product in presence of static discharge

  N/A

  Fire Fighting Media and Instructions

  Small Fire

  Use DRY chemical powder.

  Large Fire

  Use water spray, fog or foam. Do not use water jet.

  Special Remarks on Fire Hazards

  N/A

  Special Remarks on Explosion Hazards

  N/A

• Section 6 – ACCIDENT RELEASE MEASURES

  Small Spill

  Use appropriate tools to put the spilled solid in a convenient waste disposal container.

  Large Spill

  Use a shovel to put the material into a convenient waste disposal container.

• Section 7 – HANDLING AND STORAGE

  Precaution

  Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If you feel unwell, seek medical attention and show the label when possible. Avoid contact with skin and eyes.

  Storage

  Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in a cool, well-ventilated place. High toxic or infectious materials should be stored in a separate locked safety storage cabinet or room.

• Section 8 – EXPOSURE CONTROLS / PERSONAL PROTECTION

  Engineering Controls

  Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.

  Personal Precautions

  Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.

  Personal Protection in Case of a Large Spill

  Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self-contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.

  Exposure Limits

  N/A

• Section 9 – PHYSICAL AND CHEMICAL PROPERITIES

  Physical state and appearance

  Solid (Powdered Solid)

  Odor

  N/A

  Taste

  N/A

  Colour

  N/A

  pH

  N/A

  Boiling Point

  N/A

  Melting Point

  195°C (383°F)

  Critical Temperature

  N/A

  Specific Gravity

  N/A

  Vapor Pressure

  N/A

  Vapor Density

  N/A

  Volatility

  N/A

  Odor Threshold

  N/A

  Water/Oil Dist. Coeff.

  N/A

  Iconicity (in Water)

  N/A

  Dispersion Properties

  N/A

  Solubility

  N/A

• Section 10 – STABILITY AND REACTIVITY

  Stability

  The Product is stable.

  Instability Temperate

  N/A

  Condition of Instability

  N/A

  Incompatibility with Various Substance

  Reactive with oxidizing agents.

  Corrosivity

  N/A

  Special Remarks on Reactivity

  N/A

  Special Remarks on Corrosivity

  N/A

  Polymerization

  Will not occur.

• Section 11 – TOXICOLOGICAL INFORMATION

  Routes of Entry

  Dermal Contact. Eye Contact. Inhalation. Ingestion.

  Toxicity to Animals

  Acute Oral Toxicity (LD50)

  135 mg/kg [Mouse].

  Chronic Effects on Humans

  The substance is toxic to blood, the nervous system, liver.

  Other Toxic Effects on Humans

  Extremely hazardous in case of Ingestion. Hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. Slightly hazardous in case of skin contact (permeator).

  Special Remarks on Toxicity to Animals

  N/A

  Special Remarks on Chronic Effects to Human

  N/A

  Special Remarks on other Toxic Effects on Human

  N/A

• Section 12 – ECOLOGICAL INFORMATION

  Ecotoxicity

  N/A

  BOD5 & COD

  N/A

  Products of Biodegradation

  Possibly hazardous short-term degradation products are not likely. However, long term degradation products may arise.

  Toxicity of the Products of Biodegradation

  The product itself and its products of degradation are not toxic.

  Special Remarks on the Products of Biodegradation

  N/A

• Section 13 – DISPOSAL CONSIDERATION

  No data Available.

• Section 14 – TRANSPORT INFORMATION

  DOT Classification

  Class 6.1: Poisonous material.

  Identification

  Toxic Solids N.O.S.: UN2811 PG: N/A

  Special Provisions for Transport

  N/A

• Section 15 – REGULATORY INFORMATION

  Federal and State Regulations

  TSCA 8 (b) Inventory

  Chlorpromazine HCL

  Other Regulations

  N/A

  Other Classifications

  WHMIS (Canada)

  CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC). CLASS D-2B: Material causing other toxic effects (TOXIC).

  DSCL (EEC)

  R38

  Irritating to skin

  R41

  Risk of Serious damage to eyes.

  R48/25

  Toxic: Danger of serious damage to health in case of prolonged exposure if swallowed.

  HMIS (U.S.A):

  Health Hazard

  3

  Fire Hazard

  1

  Reactivity

  0

  Personal Protection

  E

  U.S.A. :

  Health

  1

  Flammability

  1

  Reactivity

  0

  Specific hazard

  N/A

  Protective Equipment

  Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses.

• Section 16 – OTHER INFORMATION

  Global Pharma provides information contained herein in good faith but makes no representation as to its comprehensives or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product.

  Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.

  GLOBAL PHARMA MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESSED OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OR MERCHANTABILITY, FITNESS FOR A PARTICULER PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT WHICH THE INFORMATION REEFERS. GLOBAL PHARMA WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF RELIANCE UPON THIS INFORMATION.