Cetrimide is an antiseptic which is a mixture of different quaternary ammonium salts including Cetrimonium bromide (CTAB). It was first discovered and developed by ICI and introduced under the brand name Cetavlon. It is used as a 1-3 % solution for cleaning road side accident wounds. Another antiseptic Chlorhexidine was also discovered and first developed by ICI. ICI also introduced Savlon which was a combination of Cetrimide and Chlorhexidine. ICI later sold the Savlon brand OTC to Johnson & Johnson in May 1992.

Certificate of Analysis

• Description

  White or creamy white, voluminous, free- flowing powder; odour, faint and characteristic.

  Result

  White or creamy white, voluminous, free-flowing powder; odour, faint and characteristic.

• Solubility

  Freely soluble in water, in ethanol (95%) and in chloroform; practically insoluble in ether.

  Result

  Freely soluble in water, in ethanol (95%) and in chloroform; practically insoluble in ether.

• Identification

  To Comply the test as per IP.

  Result

  Test A, B, C & D are Complies.

• Acidity or alkalinity

  NMT 0.1 ml of either 0.1M HCL or 0.1 M NAOH is required to change the colour of Solution.

  Result

  Complies

• Amine salts

  To Comply the test as per IP.

  Result

  Complies

• Sulphated Ash

  NMT 0.5 % w/w

  Result

  0.11 %

• Loss on drying

  NMT 2.0 % w/w

  Result

  0.20 %

• Clarity & colour of solution

  A 2.0% w/v solution is clear and colourless

  Result

  Complies.

• Assay (on dry basis)

  NLT 96% w/w & NMT 101% w/w.

  Result

  99.80 %

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Material Safety Data Sheet

• Section 1 – Chemical Product

  Product Identifier

  Ceramide

  MSDS Prepared By

  R&D Department

• Section 2 – Composition / Information Of Ingredients

  Product Name

  Ceramide

  Synonym

  Ceramide BP, Ceramide Powder

  CAS Number

  1119-97-7

• Section 3 – HAZARDOUS IDENTIFICATION

  Most Important Hazards

  The usual precautions taken when handling of product should be observed. As the substance is non-edible product, no hazardous to water supply edible.

• Section 4 – FIRST AID

  Skin Contact

  Get Medical Aid. Flush Skin With Plenty Of Water For 15 Minutes While Removing Contaminated Clothing & Shoes. Wash Clothing Before Reuse.

  Eye Contact

  Immediately Flush Eyes With Plenty Of Water For At Least 15 Minutes Lifting Lower And Upper Eyelids Occasionally. Get Medical Aid.

• Section 5 – FIRE FIGHTING MEASURES

  Extinguishing Media

  Extinguishing Media Use dry chemicals or carbon dioxide CO2. Thermal Decomposition Dangerous decomposition is not anticipated.

• Section 6 – ACCIDENT RELEASE MEASURES

  Personal Precautions

  Avoid dust formation. Use personal protective clothing.

  Environmental Precautions

  Contain contaminated water/firefighting water. Do not discharge into drains/ surface waters and groundwater.

  Cleanup

  Avoid raising dust.

  For small amounts

  Pick up with suitable appliance and dispose of

  For large amounts

  Contain with dust binding material and dispose.

• Section 7 – HANDLING AND STORAGE

  Handling / Stroge

  Breathing must be protected when large quantities are decanted without local exhaust ventilation.

  Protection against fire and explosion

  Avoid dust formation. Take precautionary measures against static discharges.

  Storage

  General advice: Keep container tightly closed and dry; store in a cool place.

• Section 8 – EXPOSURE CONTROLS / PERSONAL PROTECTION

  Occupational Exposure Limits

  Wear a NIOSH-certified (or equivalent) organic certified vapor/particulate respirator.

  Hand protection

  Chemical resistant protective gloves.

  Eye protection

  Safety glasses with side-shields.

  General safety and hygiene measures

  Wash soiled clothing immediately.

• Section 9 – PHYSICAL AND CHEMICAL PROPERITIES

  Form

  Powder

  Odor

  Odorless

  Odor threshold

  N/A

  Color

  White

  pH Value

  4 – 6 (2 g/l, 20 °C) (as suspension)

  Density

  N/A

  Bulk density

  500 kg/m3

  Solubility in water

  Miscible

• Section 10 – STABILITY AND REACTIVITY

  Conditions to avoid

  Avoid humidity.

  Hazardous reactions

  The product is not a dust explosion risk as supplied; however, the buildup of fine dust can build-up lead to a risk of dust explosions.

  Hazardous decomposition Products

  No hazardous decomposition products if stored and handled as prescribed/indicated.

• Section 11 – TOXICOLOGICAL INFORMATION

  Acute Toxic Oral

  Type of value

  LD50

  Species

  Rat

  Value

  > 10,000 mg/kg

  Irritation

  Skin

  Inhalation Skin

  Species

  Rabbit

  Result

  Non-irritation

  Eye

  Result

  Non-irritation

• Section 12 – ECOLOGICAL INFORMATION

  The product is water soluble and may spread in water systems. Mobility degradability: The product is expected to be biodegradable.

• Section 13 – DISPOSAL CONSIDERATION

  Waste Disposal

  Uncontained packaging can be rare-used. Packs that cannot be cleaned should be disposed of in the same manner as the contents.

• Section 14 – TRANSPORT INFORMATION

  Land Transport

  TDG

  Not classified as a dangerous good under transport regulations.

  Sea Transport

  IMGD

  Not classified as a dangerous good under transport regulations

  Air Transport (IATA)

  IATA/ICOA

  Not classified as a dangerous good under transport regulations

• Section 15 – REGULATORY INFORMATION

  Not Hazardous Cargo. Keep separated from hazardous chemicals.

• Section 16 – OTHER INFORMATION

  Global Pharma provides information contained herein in good faith but makes no representation as to its comprehensives or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product.

  Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.

  GLOBAL PHARMA MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESSED OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OR MERCHANTABILITY, FITNESS FOR A PARTICULER PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT WHICH THE INFORMATION REEFERS. GLOBAL PHARMA WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF RELIANCE UPON THIS INFORMATION.